It's all to play for in Group F at this stage and with Shakhtar facing Real Madrid in tonight's other game, the chance is there for either Leipzig or Celtic to make up some ground and level the playing field at the top of the table.
And after a series of bad luck in front of goal in their opening two games, Ange Postecoglou will be hoping his team can finally start racking up some European goals and pick up their first win of the campaign. The Australian has taken heart from their performances against Real and Shakhtar but their conversion rate has been the major cause for concern. They've netted 27 in the Premiership but have just one in the Champions League so far – and it wasn't even a Celtic player that scored it.
The games don't get much easier though as they travel to Germany to face a Leipzig team who have shown signs of a resurgence under Marco Rose with a 4-0 victory over Bochum at the weekend seeing Timo Werner get back among the goals. It's set to be a thrilling encounter in Leipzig but who will come out on top?
Record Sport's writers have made their picks ahead of the big one.
Craig Swan
Celtic have been good in their two group matches so far without getting the results they wanted. But unfortunately the Germans are finding their form again, so home advantage may just count in the Red Bull Arena.
Leipzig 2 Celtic 1
David McCarthy
Both teams are better going forward than they are in defence so there will be chances and goals. A draw would be a decent result for Celtic and it’s the least they will get.
Leipzig 2 Celtic 2
Keith Jackson
If Celtic can get back home with a second Group F point in their luggage then they’ll have given themselves a real chance of securing second place and a crack at the knock-out rounds. But - with Timo Werner and Christopher Nkunku leading Leipzig’s attack against a weakened back four - it does feel like a long shot.
RB Leipzig 3 Celtic 1
Robbie Copeland
With 26 shots and 10 on target over their last two Champions League games, the stats suggest something has to give for Celtic eventually. And while Leipzig are finding their feet again under Marco Rose, there are vulnerabilities there to be exposed. It will be a thrilling game that might just tip the visitors' way if they finally get some luck in front of goal.
RB Leipzig 2 Celtic 3
Gavin Berry
The Germans seem to have found their shooting boots after the weekend thumping of Bochum and in Timo Werner and Christopher Nkunku will likely have too much firepower for the visitors. But with Ange Postecoglou refusing to compromise his playing style, Celtic will have a go and can find the net themselves.
RB Leipzig 4 Celtic 2
Andy Newport
The Germans were dumped out of last season’s Europa League by Rangers but created enough chances at home to have edged past the Ibrox side. If they’re sharper with their shooting they will just have too much for Celtic.
Leipzig 2 Celtic 1
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